Depp, born June 9, 1963, in Owensboro, Ky., made his film debut in a supporting role in "A Nightmare on Elm Street" in 1984.
He also had a small part as the soldier, Lerner, in director Oliver Stone's 1986 Best Picture Oscar winner, "Platoon."
Depp's big break came with a starring role as Officer Tom Hanson in the television drama "21 Jump Street," from 1987-1990.
Johnny Depp's first film with his frequent collaborator, director Tim Burton, came in 1990 with the title role in "Edward Scissorhands."
Johnny Depp's second film with Burton came in 1994 with the title role in "Ed Wood." The biopic about the famed D-movie director also starred Martin Landau, pictured right, who won an Oscar for playing horror film icon Bela Lugosi.
In 1994, Johnny Depp starred in the drama "Don Juan De Marco."
The following year saw him tackle the thriller "Nick of Time," which tried the real-time gimmick six years before "24" came along.
In 1997, Depp helped make "fughedaboutit" popular slang opposite Al Pacino in the crime drama "Donnie Brasco."
Depp honored one of his heroes, writer Hunter S. Thompson, in a starring role in "Fear and Loathing in Las Vegas" in 1998. The film also starred Benecio Del Toro, pictured left.
In 1999, Johnny Depp teamed with Tim Burton for the third time, this time with a quirky take on the iconic character Ichabod Crane in the horror thriller "Sleepy Hollow."
In 2000, Johnny Depp charmed audiences as Roux in the romantic drama "Chocolat."
In 2001, Depp starred in the crime drama "Blow."
Also in 2001, Depp took on a role in the Hughes Brothers' period thriller "From Hell."
In 2003, Depp set sail with Orlando Bloom for the high seas adventure "Pirates of the Caribbean: The Curse of the Black Pearl."
Johnny Depp starred as "Peter Pan" author J.M. Barrie in the 2004 drama "Finding Neverland."
Despite his broad appeal, Johnny Depp took time to star in smaller films, including his role as Rochester in the 2004 period drama "The Libertine."
In 2004, Johnny Depp also starred in the mystery drama "Secret Window."
In 2005, Depp partnered with Tim Burton for a fourth time to give a new spin to "Charlie and the Chocolate Factory."
Depp's fifth collaboration with Burton came in 2005 as the voice of Victor Van Dort, opposite Helena Bonham, who voiced the title role in "Corpse Bride."
He reprised his role as Capt. Jack Sparrow in the second "Pirates of the Caribbean" movie, "Dead Man's Chest," in 2006.
Johnny Depp's sixth film with Tim Burton came in 2007 with the title role in "Sweeney Todd," which earned Depp his third Best Actor Oscar nomination.
Director Tim Burton and Depp on the set of "Sweeney Todd: The Demon Barber of Fleet Street."
Depp signed up for another chance to play Capt. Jack Sparrow in "Pirates of the Caribbean: At World's End" in 2007.
In 2009, Depp starred as gangster John Dillinger in "Public Enemies."
Johnny Depp as the Mad Hatter in "Alice in Wonderland," his seventh film with Tim Burton. Depp earned a Golden Globe nomination for the role.
Johnny Depp with Tim Burton on the set of "Alice in Wonderland."
Depp lent his voice to the title character in "Rango," which was helmed by Gore Verbanski, director of the first three "Pirates of the Caribbean" movies.
Depp returned as Capt. Jack Sparrow for a fourth time in "Pirates of the Caribbean: On Stranger Tides," co-starring Penelope Cruz and Ian McShane.
In October 2011, Depp starred in "The Rum Diary," a semi-autobiographical novel by Hunter S. Thompson.
Depp reunited with Tim Burton for the movie adaptation of the cult favorite "Dark Shadows," a soap opera that ran from 1966 to 1971.