Keolu Drive was closed in both directions between Akeke Place and Akipohe Street in Kailua due to a house fire investigation, according to Honolulu police.
Fire crews were called to the 2-alarm fire at around noon.
A 48-year-old man suffered second-degree burns to his arm and shoulder, according to Emergency Medical Services officials. He was hospitalized in stable condition.
A 52-year-old man was hospitalized in stable condition due to smoke inhalation.
Damage estimates has been determined at $600,000.
The fire was called under control by 12:23 p.m. The road was reopened by 2:17 p.m.
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